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Also Known As: δ* KI δ* KI is a CRISPR/cas9-made knock-in allele with a T269Y mutation in Gabrd exon 8 that renders δ-containing receptor populations insensitive to picrotoxin (PTX). These mice allow chemogenetic isolation of δ-containing GABAA receptors, and may be useful for neurological studies of receptor, ion channel and synapse biology, neurotransmitters, and glutamate/GABA transmission.

Key alcoholism gene influences how quickly body metabolizes alcohol

Brain changes evident in scans before memory, cognitive decline

I​n 2012, Andrew and Barbara Taylor and the Crawford Taylor Foundation pledged $20 million to the Department of Psychiatry at Washington University’s School of Medicine to establish a research institute dedicated to advancing new treatments for mental illnesses. Just six years later, investigators in the department’s Taylor Family Institute for Innovative Psychiatric Research are on […]

A $10 million commitment from Andrew Taylor, a life trustee at Washington University in St. Louis, and his wife, Barbara, will establish the Taylor Family Scholarship Challenge, which will match all new and increased gifts for undergraduate scholarships received by the conclusion of Leading Together: The Campaign for Washington University on June 30, 2018, as well as […]

Grant to renew annual clinic, advance understanding of rare disorder

In the new research, Steve Mennerick, Institute scientific director, and his colleagues focused on GABA receptors located on neurons in the brain’s hippocampus, a part of the brain involved in learning and memory. Using CRISPR, they mutated the delta-type GABA receptors to isolate and test their role in brain functioning.